Greetings from the Editorial board of Chettinad Health City Medical Journal. With immense pleasure, we bring out the final issue of Volume 6. We thank the authors and the reviewers whose sustained support has helped us stride forward. The existence and sustainability of a species depends on its ability to procreate. There have been reports of gradual extinction of species due to habitat degradation, increasing environmental toxicity thereby reducing their ability to reproduce. The perspective article emphasizes on the significance of reproduction, and why infertility and its treatment deserve equal attention from the authorities, as the other health problems.

Facial aesthetics affects how people are perceived by society and how they perceive themselves. Aesthetics includes the appearance of an individual and the dentition plays an important role in facial appearance. The indices currently in use to assess malocclusion lack the assessment of psychosocial component. The present study has been undertaken to determine the psychological as well as social impact of dental aesthetics and to investigate self-perceived need for orthodontic treatment.

Mucormycosis is an invasive fungal infection most commonly affecting immuno-compromised individuals. It is a rapidly progressive, life threatening infection. Objective To study the various treatment modalities and their outcome

The human reproduction is achieved as the domino effect of successful synchronization and communication between the embryo and the uterine endometrium. Here the embryo is thought to be the most important factor for achieving a pregnancy in assisted reproductive technology (ART). These embryos were cultured in culture media containing various vital components, of which the buffers for maintaining the pH play an imperative role. The bicarbonate buffer being the oldest & most commonly used buffer in Assisted Reproductive Technology(ART) for handling gametes and culturing them as embryos is now replaced by 4-2-hydroxyethyl-1-piperazine ethane sulfonic acid (HEPES) & 3-N-morpholino propane sulfonic acid (MOPS) organic based buffers for collection and manipulation of gametes.

Here I report about a 49 years old HIV positive male patient who developed Anti-Retro viral Therapy-induced Fanconi Syndrome and consequently had bilateral pathologic neck of Femur fractures. I suggest that the retro viral infection together with the long-term usage of anti-retroviral drugs may have contributed to the patient's pathologic fractures by aggravating bone demineralisation. This case highlights the importance of monitoring not only for renal impairment but also for bone disease in patients receiving Highly Active Anti-Retroviral Therapy (HAART).

Pituitary Stalk Interruption Syndrome (PSIS) is a rare congenital anomaly of pituitary gland characterized by triad of thin or interrupted pituitary stalk, aplasia or hypoplasia of the anterior pituitary and an absent or ectopic posterior pituitary (EPP) seen on magnetic resonance imaging (MRI). PSIS is associated with several midline malformations including facial dysmorphism, septal agenesis, partial corpus callosum agenesis, aqueductal stenosis, optic nerve hypoplasia, craniopharyngeal canal, cleft lip and palate. The anaesthetic management of a patient with hypopituitarism presents several problems like precipitating acute adrenal crisis, decreased resting cardiac output which cannot be increased when stressed, relative hypovolemia on induction, low basal metabolic rate and an inability to increase core temperature. The anaesthetic management of a four-year-old boy diagnosed to have growth hormone deficiency with early childhood caries for pulpectomy and root canal treatment under genral anaesthesia is discussed.

Gender equality and the role of women in medicine is always a matter of increasing interest to the medical fraternity. While we continue to debate about equal rights for women and equal pay in the current climate, it is intriguing to reflect on our history of the first few women doctors in India in the 19th century. It is unfathomable, that with the lack of equality of civil rights, that these women managed to get their names etched in the history of modern Indian medicine. However, they did it and in style. Their life accounts are not lacking in strength, struggle and tenacity.

Chronobiology is the study of molecular basis of the internal biological rhythms and their impact on the functioning of an organism. There are three basic cycles of chronobiology. The names of cycles were derived from latin words.

Life appeared on planet earth millions of years ago, probably by accident. Since time immemorial there has been a compelling biological urge and necessity to procreate, in order to sustain one’s species and to continue the existence of life in the planet.