Natural Products of Therapeutic Potential The use of herbs for healing and treating diseases precedes recorded human history probably by thousand of years. Over the ensuing millennia, humankind discovered and made use of an enormous range of natural compounds. In earlier research, many natural products helped us to reveal a novel aspect of physiology. For example, digitalis from foxglove showed the role of sodium-potassium ATPase, morphine pointed the way to the receptors a effected by endogenous opioids, muscarine, nicotine and tubocurarine helped explore the different types of acetylcholine receptors and so on.

Physalis angulata, commonly called as angular winter cherry or balloon cherry is the most extensively used herbal plant as an antidiuretic. This study aims at synthesizing zinc oxide nanoparticles from the plant extract and testing it against kidney stones. The nanoparticles were synthesized from the aqueous extract of the plant, characterized using spectroscopic methods and were analyzed against calcium oxalate crystals. The rate of degradation of calcium oxalate was analyzed using FTIR technique. The results were encouraging which indicated the decrease in the concentration of calcium oxalate as the reaction time increased. This study can form a foundation for producing a new technique in treating kidney stones using nanoparticles without any side effects.

The environmental factors, photoperiod and various experimental condition such as melatonin (MEL) and testosterone propionate (TP) hormone treatment play an important role in regulating the physiological activity in adult male domestic pigeons. Exposed constant photoperiod (24L: 0D) with exogenous MEL and TP hormone treatment at a daily dose of 20 µg/ 100gm body weight and at a daily dose of 1 mg/ 100gm body weight for 15 days treatment respectively in breeding and non breeding seasons. With constant illumination (24L : 0D) and melatonin treatment for 15 days in primary breeding season, the experimental birds exhibited adreno-cortical activity such as the number of mitochondria and lipid granuoles were increased and lysosomes. Golgi complex and smooth endoplasmic reticulum were decreased than the control birds. Where pinealocytes were decreased minimally and the Golgi complex showed the typical dictyosomal structure.

Aging process is associated with the accumulation of free radicals that tilts cellular homeostasis leading to cellular senescence. The Speci c Bioactive Fraction (SBF) from Rhodiola plant in combination with a class of lipoproteins (LF) derived from the fish Trachurus sp contains bioactive compounds mainly rhodioloside or salidroside which has capability to quench oxidative stress and exhibits anti-infammatory effects with immuno-enhancing and modulating properties. Hence, in this study we tested the bioactive compound (R-L) in Caulobacter cresentus against induced oxidative stress

Rats fed high dietary fructose are documented to form an acquired model of insulin resistance leads to diabetes mellitus. The present work investigates the involvement of kinins in the effects of chrysin in high fructose-fed rats' leads to hypertensive conditions. Previous studies show that chrysin promotes insulin sensitivity in fructose-fed rats

This 1st E international conference CHETPHYSIOCON 2021 on Functional Based Physiotherapy Intervention held in the Chettinad School of Physiotherapy, CARE, Chennai. This conference provided an international forum to present, discuss and exchange innovative ideas and recent developments in the field of Women’s Health, Geriatric health, Pediatric Health and Hand injury.

It is a matter of immense pleasure that Chettinad School of Physiotherapy, Chettinad Academy of Research and Education (CARE),Kelambakkam , Chennai is organizing the first E- International Conference CHETPHYSIOCON 2021 with the theme titled “Functional Based Physiotherapy Intervention” to be held on 30/04/2021

I would like to congratulate the Chettinad School of Physiotherapy, Chettinad Academy of Research and Education (CARE), Kelambakkam, Chennai for their commitment and superb drive in organizing this virtual conference.

On behalf of the Organizing team, it gives me immense pleasure and joy to welcome all distinguished delegates, invitees, faculties, students, research scholars for attending the first E- International Conference CHETPHYSIOCON 2021 with the theme titled “Functional Based Physiotherapy Intervention” to be held on 30/04/2021.

In Stroke, Constraint-Induced Movement Therapy (CIMT), Neuromuscular Electrical Stimulation (NMES) or Motor Imagery are some of the most common therapies for motor rehabilitation of the hemiplegic arm. But Major limitation in these techniques is, they are not appropriate for patients in chronic stage with moderate or severe impairment. In SCI, Prolonged use of wheelchairs leads to decreased physical activity.

The Nobel Prize for physiology or medicine has been awarded jointly to Harvey Alter, Michael Houghton, and Charles Rice for the discovery of hepatitis C virus (HCV). This remarkable invention not only transformed the fields of virology or immunology but also saved millions of lives revolutionizing clinical care and management in terms of proper diagnosis using sensitive tests, effective treatment to cure HCV infection and for the prevention of liver cancer in a large number of populations. Through this review, Chettinad Health City Medical Journal honours Harvey Alter, Michael Houghton, and Charles Rice for their great e ort and contribution.

Naturally occurring plant derived steroidal saponins play a remarkable role to combat various diseases, especially cancer. Diosgenin is a steroidal saponin, which has various properties including antimicrobial, antiviral, anti-inflammatory, anti-diabetic, hypercholesterolemia, and as well as anti-cancer activities.

The traditionalplant psidiumguajava Linn is commonly known as Guava in India, belongs to Myrtaceae family. The whole plant is used in traditional medicine [Bark,Leaves,Fruits and Roots] for various types of infammatory and wound conditions. Phytochemical review showed that the plant was found to contain rich amount of Tannin, a polyphenolic compound. Due to the presence of different types of Tannin, the plant showed a remarkable wound healing property in all types of wounds, it was proved by scientific data. Based on its wide application in local medicine and in Indian system of medicine as anti-infammatory drug in the treatment of wounds, the present review gives an update on psidiumguajava about its wound healing activity by both in-vitro and in-vivo methods.

Lycopene is a bioactive compound primarily found in tomato. It is described by an agent with high cancer prevention potential. Predominantly because of this property, lycopene has been recommended to show numerous advantageous impacts, including its potential as anti-cancerand cardio protective agent. The studies suggested that the consumption lycopene in food or by itself may reduce cancer and cardiovascular disease risk. However, there are insufficient clinical trial data to support the hypothesis. It acts by multiple mechanisms including the regulation of growth factor signaling, cell cycle arrest and/or apoptosis induction, metastasis and angiogenesis, as well as by modulating the anti-inflammatory and phase II detoxification enzymes activities. In this review, the anti-cancer and cardioprotective properties of lycopene are discussed.