Greetings from the Editorial Board of Chettinad Health City Medical Journal! Advances in early cancer diagnosis and treatment regimens have significantly improved survival rates, allowing patients and professionals to think beyond the cure for cancer to the future quality of life. Fertility impairment is a significant concern for many pediatric, adolescent and young adult cancer survivors.

To understand the age related sensitivity of human and mouse sperm chromatin to radiation. This prospective study examined the comparative in vitro radiosensitivity of sperm DNA from normozoospermic human ejaculate (N= 47) and mouse epididymal spermatozoa (N= 40), from various age groups. Human ejaculates and mouse sperm suspension were exposed to 0 and 5 Gy,-radiation using 60Cobalt tele-therapy unit and sperm DNA damage was assessed by single cell gel electrophoresis (neutral comet assay).

With advancement in assisted reproduction technology, cryopreservation has now become an essential aspect of in vitro fertilization cycle. While this technology was considered to have potential benefit in Assisted Reproductive Technology (ART) earlier, in recent times it has also found its place in fertility preservation with increasing awareness and knowledge of cancer treatment and its consequences. This review gives an overview of importance of cryopreservation technology in infertility treatment and fertility preservation.

Since time immemorial, Moringa oleifera Lam. (MO) is a highly valued plant with potential application in the area of nutrition and medicine. All parts of the plant have been used in preparing Ayurvedic medicines while the leaves and pods have been used in preparing traditional dishes. The leaves of this plant are most commonly used as they are rich in amino acids, vitamins, poly-phenols, flavonoids, alkaloids and phytosterols, which attribute to the nutritive and medicinal properties. The tissue and cyto-protective action of MO against various toxic agents is gaining tremendous importance in the field of toxicology. However, very few reports have highlighted the protective effect of MO and its active components against gonadotoxic agents. The present review mainly focuses on the medicinal properties of MO with special reference to its role in male fertility preservation.

Fertility preservation is the cryopreservation of gametes (spermatozoa, oocytes), embryos, testicular tissue, and ovarian tissue in order to have a choice of reproduction in the future. This is crucial in patients affected with cancer or other severe medical diseases whose treatment hampers the fertility potential of an individual. Fertility preservation however, raises a lot of ethical issues in each group of patients.

Procreation and parenthood has always been central to human culture and society. There are many who experience situations that affect their future pregnancy adversely. These range from voluntary choice to delay conception till a later date or diseases and treatments that affect future fertility. Earlier there were not too many options for fertility preserving other than planning pregnancy early or cryopreserving sperm. With the advent of assisted reproductive technologies (ART) new tools for fertility conservation have emerged; ovarian cortex, oocyte or embryo cryopreservation. Surgical and pharmacotherapeutic advancements have helped in improving the scope of fertility preservation in oncology.

I am your skin Closer than your kin I hold you tight like a wife But for me there is no life.